Today I needed to reduce size of CSS and JS which was almost 400Kb all together. Spending some time found usefull tools for it.
http://iceyboard.no-ip.org/projects/css_compressor and http://dojotoolkit.org/docs/shrinksafe are winners
Before compressing javascript file make sure that You don’t have anything compressed already there, all lines are ending with semicolon and all code is valid.
After compression I saved 80Kb.
Finally we have changed CDN from amazon S3 to cachefly, and it is much quicker and they support gzip on-fly
